The Mercedes-Benz S-Class Long (V221) S 350 4MATIC, produced from 2005 to 2009, represented a compelling blend of luxury, technology, and performance within the flagship S-Class range. Positioned as a mid-range offering in the long-wheelbase (Long) variant, it catered to buyers seeking a spacious and refined experience without the outright performance of the higher-tier S 500 or S 600 models. This model was primarily aimed at the European and Asian markets, where the preference for long-wheelbase luxury sedans was particularly strong, though it was also available in the United States. The V221 generation S-Class, overall, was a significant leap forward in automotive technology, introducing innovations like Pre-Safe brake assist and Active Body Control suspension.
Technical Specifications
| Brand | Mercedes-Benz |
| Model | S-Class |
| Generation | S-Class Long (V221) |
| Type | S 350 (272 Hp) 4MATIC 7G-TRONIC |
| Start of production | 2005 |
| End of production | 2009 |
| Powertrain Architecture | Internal Combustion engine |
| Body type | Sedan |
| Seats | 5 |
| Doors | 4 |
| Fuel consumption (urban) | 15.1-15.3 l/100 km (15.6 – 15.4 US mpg, 18.7 – 18.5 UK mpg, 6.6 – 6.5 km/l) |
| Fuel consumption (extra urban) | 8.3-8.5 l/100 km (28.3 – 27.7 US mpg, 34 – 33.2 UK mpg, 12 – 11.8 km/l) |
| Fuel consumption (combined) | 10.7-10.9 l/100 km (22 – 21.6 US mpg, 26.4 – 25.9 UK mpg, 9.3 – 9.2 km/l) |
| CO2 emissions | 256-261 g/km |
| Fuel Type | Petrol (Gasoline) |
| Acceleration 0 – 100 km/h | 7.3 sec |
| Acceleration 0 – 62 mph | 7.3 sec |
| Acceleration 0 – 60 mph | 6.9 sec |
| Maximum speed | 250 km/h (155.34 mph) |
| Weight-to-power ratio | 7.1 kg/Hp, 141.7 Hp/tonne |
| Weight-to-torque ratio | 5.5 kg/Nm, 182.3 Nm/tonne |
| Power | 272 Hp @ 6000 rpm |
| Power per litre | 77.8 Hp/l |
| Torque | 350 Nm @ 2400-5000 rpm (258.15 lb.-ft. @ 2400-5000 rpm) |
| Engine layout | Front, Longitudinal |
| Engine Model/Code | M 272.965 |
| Engine displacement | 3498 cm3 (213.46 cu. in.) |
| Number of cylinders | 6 |
| Engine configuration | V-engine |
| Cylinder Bore | 92.9 mm (3.66 in.) |
| Piston Stroke | 86 mm (3.39 in.) |
| Compression ratio | 10.7:1 |
| Number of valves per cylinder | 4 |
| Fuel injection system | Multi-port manifold injection |
| Engine aspiration | Naturally aspirated engine |
| Valvetrain | DOHC |
| Engine oil capacity | 8 l (8.45 US qt | 7.04 UK qt) |
| Coolant | 8.5 l (8.98 US qt | 7.48 UK qt) |
| Kerb Weight | 1920 kg (4232.88 lbs.) |
| Max. weight | 2580 kg (5687.93 lbs.) |
| Max load | 660 kg (1455.05 lbs.) |
| Trunk (boot) space – maximum | 560 l (19.78 cu. ft.) |
| Fuel tank capacity | 90 l (23.78 US gal | 19.8 UK gal) |
| Length | 5209 mm (205.08 in.) |
| Width | 1872 mm (73.7 in.) |
| Width including mirrors | 2115 mm (83.27 in.) |
| Height | 1473 mm (57.99 in.) |
| Wheelbase | 3165 mm (124.61 in.) |
| Front track | 1604 mm (63.15 in.) |
| Rear (Back) track | 1606 mm (63.23 in.) |
| Front overhang | 871 mm (34.29 in.) |
| Rear overhang | 1173 mm (46.18 in.) |
| Minimum turning circle | 12.2 m (40.03 ft.) |
| Drive wheel | All wheel drive (4×4) |
| Number of gears | 7 |
| Gearbox type | automatic transmission |
| Front suspension | Independent multi-link suspension |
| Rear suspension | Independent multi-link suspension |
| Front brakes | Ventilated discs |
| Rear brakes | Disc |
| Steering type | Steering rack and pinion |
| Tires size | 235/55 R17 W |
| Wheel rims size | 8J x 17 |
Powertrain & Engine Architecture
The S 350 4MATIC utilized the M272.965 3.5-liter naturally aspirated V6 engine. This engine was a cornerstone of Mercedes-Benz’s mid-range offerings during this period. It featured a 60-degree V-angle, a magnesium block, and aluminum cylinder heads. The engine employed multi-port fuel injection and a double overhead camshaft (DOHC) valvetrain with four valves per cylinder. The M272 engine family was known for its smooth operation and relatively high specific output. Paired with the engine was the 7G-TRONIC seven-speed automatic transmission, a significant advancement over previous five-speed automatics. The 7G-TRONIC offered smoother shifts, improved fuel efficiency, and a wider gear ratio spread. The 4MATIC all-wheel-drive system distributed power to all four wheels, enhancing traction and stability, particularly in adverse weather conditions.
Driving Characteristics
The S 350 4MATIC offered a comfortable and refined driving experience, prioritizing smoothness and quietness over outright performance. With 272 horsepower and 350 Nm (258 lb-ft) of torque, acceleration was respectable, achieving 0-60 mph in around 6.9 seconds. However, it wasn’t as brisk as the S 500 or S 600 models. The 7G-TRONIC transmission contributed to relaxed cruising, with well-spaced gear ratios. The all-wheel-drive system provided confident handling in various conditions. Compared to the manual transmission options available on some other S-Class variants, the automatic prioritized ease of use and convenience, appealing to a broader audience. The power delivery was linear and predictable, making it easy to modulate in city traffic or on the highway.
Equipment & Trim Levels
The S 350 4MATIC came standard with a comprehensive array of luxury features, befitting its flagship status. These included leather upholstery, wood trim, dual-zone automatic climate control, a premium sound system, and power-adjustable front seats with memory function. Standard safety features included multiple airbags, anti-lock brakes, and electronic stability control. Optional extras included a panoramic sunroof, rear seat entertainment system, massaging seats, and advanced parking assist features. The interior design was characterized by its elegant simplicity and high-quality materials. The long-wheelbase configuration provided ample rear legroom, enhancing passenger comfort.
Chassis & Braking
The V221 S-Class featured an independent multi-link suspension at both the front and rear, providing a comfortable ride and precise handling. The suspension was electronically controlled, adapting to road conditions and driving style. The S 350 4MATIC was equipped with ventilated disc brakes at the front and solid discs at the rear. Anti-lock brakes (ABS) and electronic brake-force distribution (EBD) were standard. The steering system was a rack-and-pinion setup with speed-sensitive power assistance. The chassis was designed to minimize noise, vibration, and harshness (NVH), contributing to the overall refined driving experience.
Market Reception & Comparison
The S 350 4MATIC was generally well-received by automotive critics. It was praised for its comfortable ride, spacious interior, and comprehensive list of standard features. However, some reviewers noted that its performance was not as exhilarating as that of the higher-powered S-Class models. Compared to the S 500, the S 350 offered a more affordable entry point into the S-Class range, while still providing a luxurious experience. In terms of fuel economy, the S 350 was more efficient than the S 500 and S 600, but its fuel consumption was still relatively high compared to more modern vehicles. Reliability was generally good, although some owners reported issues with the electronic systems.
Legacy
The Mercedes-Benz S-Class Long (V221) S 350 4MATIC remains a desirable used car today, particularly for buyers seeking a spacious and comfortable luxury sedan. The M272 engine is known for its durability, although regular maintenance is essential. The 7G-TRONIC transmission is also generally reliable, but may require servicing as it ages. The V221 S-Class represents a high point in Mercedes-Benz engineering, offering a blend of luxury, technology, and performance that continues to appeal to discerning buyers. Its advanced features and comfortable ride make it a compelling alternative to more modern luxury sedans.






